Publications 2017:
Agrawal PB, Wang R, Li HL, Schmitz-Abe K, Simone-Roach C, Chen J, Shi J, Louie T, Sheng S, Towne MC, Brainson CF, Matthay MA, Kim CF, Bamshad M, Emond MJ, Gerard NP, Kleyman TR, Gerard C. Epithelial Sodium Channel ENaC is a modifier of the long term non-progressive phenotype associated with F508del CFTR mutations. Am. J. Respir. Cell Mol. Biol. 2017, In press. PMCID In process
Al-Qusairi L, Basquin D, Roy A, Rajaram RD, Maillard MP, Subramanya AR, Staub O. Renal Tubular Ubiquitin-Protein Ligase NEDD4-2 Is Required for Renal Adaptation during Long-Term Potassium Depletion. J Am Soc Nephrol. 2017, Aug;28(8):2431-2442. PMCID PMC28289184
Apodaca G. Role of Polarity Proteins in the Generation and Organization of Apical Surface Protrusions. Cold Spring Harb Perspect Biol. 2017 Mar 6. pii: a027813. In press. PMCID In process.
Bhattacharyya S, Jean-Alphonse FG, Raghavan V, McGarvey JC, Rbaibi Y, Vilardaga JP, Carattino MD, Weisz OA. Cdc42 activation couples fluid shear stress to apical endocytosis in proximal tubule cells. Physiol Rep. 2017 Oct;5(19). pii: e13460. PMCID: PMC5641940.
Boyd-Shiwarski CR, Shiwarski DJ, Roy A, Nkashama LJ, Namboodiri HN, Xie J, McClain KL, Marciszyn A, Kleyman TR, Tan RJ, Stolz DB, Puthenveedu MA, Huang CL, Subramanya AR. Potassium-Regulated Distal Tubule WNK Bodies are Kidney-Specific WNK1 Dependent. Mol Biol Cell. 2017 Dec 13. pii: mbc.E17-08-0529. PMCID: In process.
Braganza A, Li J, Zeng X, Yates NA, Dey NB, Andrews J, Clark J, Zamani L, Wang XH, St Croix C, O'Sullivan R, Garcia-Exposito L, Brodsky JL, Sobol RW. UBE3B Is a Calmodulin-regulated, Mitochondrion-associated E3 Ubiquitin Ligase. J Biol Chem. 2017 Feb 10;292(6):2470-2484. PMCID PMC5313114
Buck TM, Jordahl AS, Yates ME, Preston GM, Cook E, Kleyman TR, Brodsky JL. Interactions between intersubunit transmembrane domains regulate the chaperone-dependent degradation of an oligomeric membrane protein. Biochem J. 2017 Feb 1;474(3):357-376. PMCID PMC5423784
Carrisoza-Gaytán R, Wang L, Schreck C, Kleyman TR, Wang WH, Satlin LM. The mechanosensitive BKα/β1 channel localizes to cilia of principal cells in rabbit cortical collecting duct (CCD). Am J Physiol Renal Physiol. 2017 Jan 1;312(1):F143-F156. PMCID PMC5283883.
Cerqueira DM, Bodnar AJ, Phua YL, Freer R, Hemker S, Walensky LD, Hukriede NA, Ho J. Bim gene dosage is critical in modulating nephron progenitor survival in the absence of microRNAs during kidney development. FASEBJ 2017, Aug;31(8):3540-3554. PMCID PMC5503708
Cheng F, Birder LA, Kullmann FA, Hornsby J, Watton PN, Watkins S, Thompson M, Robertson AM. Layer-dependent role of collagen recruitment during loading of the rat bladder wall. Biomech Model Mechanobiol. 2017 Oct 16. PMCID: In process.
Dai Y, Chen A, Liu R, Gu L, Sharma S, Cai W, Salem F, Salant DJ, Pippin J, Shankland S, Moeller M, Ghyselinck N, Ding X, Chuang PY, Lee K, He JC. Retinoic acid improves nephrotoxic serum-induced glomerulonephritis through activation of podocyte retinoic acid receptor alpha. Kidney Int. 2017, In press. PMCID In process
Dimitrion P, Zhi Y, Clayton D, Apodaca G, Wilcox, MR, Johnson JW, Nimgaonkar V, D’Aiuto, L. Low-density neuronal cultures from human induced pluripotent stem cells. Mol Neuropsychiatry. 2017, In press. PMCID In process
Emlet DR, Pastor-Soler N, Marciszyn A, Wen X, Gomez H, Humphries WH 4th, Morrisroe S, Volpe JK, Kellum JA. Insulin-like growth factor binding protein 7 and tissue inhibitor of metalloproteinases-2: differential expression and secretion in human kidney tubule cells. Am J Physiol Renal Physiol. 2017, Feb 1;312(2):F284-F296. PMCID PMC5336590
Eshbach ML, Kaur A, Rbaibi Y, Tejero J, Weisz OA. Hemoglobin inhibits albumin uptake by proximal tubule cells: implications for sickle cell disease. Am J Physiol Cell Physiol. 2017, Jun 1;312(6):C733-C740. PMCID PMC5494590
Eshbach ML, Weisz OA. Receptor-Mediated Endocytosis in the Proximal Tubule. Annu Rev Physiol. 2017, Feb 10;79:425-448. PMCID PMC5512543
Fan Y, Xiao W, Lee K, Salem F, Wen J, He L, Zhang J, Fei Y, Cheng D, Bao H, Liu Y, Lin F, Jiang G, Guo Z, Wang N, He JC. Inhibition of Reticulon-1A-Mediated Endoplasmic Reticulum Stress in Early AKI Attenuates Renal Fibrosis Development. J Am Soc Nephrol. 2017, Jul;28(7):2007-2021. PMCID PMC5491287
Fu H, Tian Y, Zhou L, Zhou D, Tan RJ, Stolz DB, Liu Y. Tenascin-C Is a Major Component of the Fibrogenic Niche in Kidney Fibrosis. J Am Soc Nephrol. 2017, Mar;28(3):785-801. PMCID PMC5328156.
Gallo LI, Dalghi MG, Clayton DR, Ruiz WG, Khandelwal P, Apodaca G. RAB27B requirement for stretch-induced exocytosis in bladder umbrella cells. Am J Physiol Cell Physiol. 2018 Mar 1;314(3):C349-C365. doi: 10.1152/ajpcell.00218.2017. Epub 2017 Nov 22. PubMed PMID: 29167152; PubMed Central PMCID: PMC6335015.
Gleixner AM, Hutchison DF, Sannino S, Bhatia TN, Leak LC, Flaherty PT, Wipf P, Brodsky JL, Leak RK. N-acetyl-L-cysteine protects astrocytes against proteotoxicity without recourse to glutathione. Mol Pharmacol. 2017, In press. PMCID In process
Guerriero CJ, Reutter KR, Augustine AA, Preston GM, Weiberth KF, Mackie TD, Cleveland-Rubeor HC, Bethel NP, Callenberg KM, Nakatsukasa K, Grabe M, Brodsky JL. Transmembrane helix hydrophobicity is an energetic barrier during the retrotranslocation of integral membrane ERAD substrates. Mol Biol Cell. 2017, Jul 15;28(15):2076-2090. PMCID PMC5509421
Hukriede N, Vogt A, de Caestecker M. Drug Discovery to Halt the Progression of AKI to CKD: a case for phenotypic drug discovery in AKI. Nephron. 2017, In press. PMCID In process
Ikeda Y, Zabbarova I, Schaefer CM, Bushnell D, De Groat WC, Kanai A, Bates CM. Fgfr2 is integral for bladder mesenchyme patterning and function. Am J Physiol Renal Physiol. 2017, Apr 1;312(4):F607-F618. PMCID PMC5407073
Jackson EK, Kotermanski SE, Dubey RK, Jackson TC, Kochanek PM. Adenosine production by brain cells. J Neurochem. 2017, Jun;141(5):676-693. PMCID PMC5429183
Jackson EK, Zhang M, Cheng D. Alkaline phosphatase inhibitors attenuate renovascular responses to norepinephrine. Hypertension 2017, 69: 484-493. PMCID PMC5310812
Jackson EK and Mi Z. 8-Aminoguanosine exerts diuretic, natriuretic, and glucosuric activity via conversion to 8-aminoguanine, yet has direct antikaliuretic effects. J Pharmacol Exp Ther 363: 358–366, 2017. PMCID: PMC5683068.
Jackson EK, ZhanY, Gillespie DD, Zhu X, Cheng D, Jackson TC. SDF-1α induces cardiac fibroblasts, renal microvascular smooth muscle cells and glomerular mesangial cells to proliferate, hypertrophy and produce collagen. J Am Heart Assoc 6: e007253, 2017. PMCID: PMC5721794.
Kashlan OB, Kinlough CL, Myerburg MM, Shi S, Chen J, Blobner BM, Buck TM, Brodsky JL, Hughey RP, Kleyman TR. N-linked Glycans are Required on Epithelial Na+ Channel Subunits for Maturation and Surface Expression. Am J Physiol Renal Physiol. 2017 Nov 29:ajprenal.00195.2017. PMCID: In process.
Keller AS, Diederich L, Panknin C, DeLalio LJ, Sherman R, Jackson EK, Kelm M, Cortese-Krott MM and Isakson BE. Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway. Am J Physiol Cell Physiol 313: C593-C603, 2017. PMCID: In process.
Kinsman BJ, Browning KN, Stocker SD. NaCl and osmolarity produce different responses in organum vasculosum of the lamina terminalis neurons, sympathetic nerve activity, and blood pressure. J Physiol 595: 6187-6201, 2017. PMCID: PMC5599491.
Klemens CA, Edinger RS, Kightlinger L, Liu X, Butterworth MB. Ankyrin G Expression Regulates Apical Delivery of the Epithelial Sodium Channel (ENaC). J Biol Chem. 2017 Jan 6;292(1):375-385. PMCID PMC5217695.
Kleyman TR, Kashlan OB, Hughey RP. Epithelial Na+ channel regulation by extracellular and intracellular Factors. Annu. Rev. Physiol. 2017, In Press. PMCID In process
Kullmann FA, Chang HH, Gauthier C, McDonnell BM, Yeh JC, Clayton DR, Kanai AJ, de Groat WC, Apodaca GL, Birder LA. Acta Physiol. 2017, In press. PMCID In process
Kullmann FA, Clayton DR, Ruiz WG, Wolf-Johnson A, Gauthier C, Kanai AJ, Birder LA, Apodaca G. Urothelial proliferation and regeneration after spinal cord injury. Am J Physiol Renal Physiol. 2017, Jul 1;313(1):F85-F102. PMCID PMC5538841
Kullmann FA. A new player in interstitial cystitis/bladder pain syndrome: platelet-activating factor - PAF and its connection to smoking. Physiol Rep. 2017, Apr;5(7):e13235. PMCID PMC5392521
Lennox AT, Coburn SL, Leech JA, Heidrich EM, Kleyman TR, Wenzel SE, Pilewski JM, Corcoran TE and Myerburg M. ATP12A promotes mucus dysfunction during Type 2 airway inflammation. Sci Rep. Feb 1;8(1):2109. PMCID: In process.
Liu X, Edinger RS, Klemens CA, Phua YL, Bodnar AJ, LaFramboise WA, Ho J, Butterworth MB. A MicroRNA Cluster miR-23-24-27 Is Upregulated by Aldosterone in the Distal Kidney Nephron Where it Alters Sodium Transport. J Cell Physiol. 2017, Jun;232(6):1306-1317. PMCID PMC5426511
Long KR, Shipman KE, Rbaibi Y, Menshikova EV, Ritov VB, Eshback ML, Jiang Y, Jackson EK, Baty CJ and Weisz OA. Proximal tubule apical endocytosis is modulated by fluid shear stress via an mTORdependent pathway. Mol Biol Cell. 28: 2508-2517, 2017. PMCID: PMC5597323.
Liu, R., Das, B., Xiao, W., Li, Z., Li, H., Lee, K., and He, J.C. A Novel Inhibitor of Homeodomain Interacting Protein Kinase 2 Mitigates Kidney Fibrosis through Inhibition of the TGF-β1/Smad3 Pathway. J Am Soc Nephrol. 2017, Jul;28(7):2133-2143. PMCID PMC5491283
Mackie TD, Kim BY, Subramanya AR, Bain DJ, O'Donnell AF, Welling PA, Brodsky JL. The endosomal trafficking factors CORVET and ESCRT suppress plasma membrane residence of the renal outer medullary potassium channel (ROMK). J Biol Chem. 2018 Jan 8. pii: jbc.M117.819086. PMCID: In process.
Marrone AK, Stolz DB, Bastacky SI, Kostka D, Bodnar AJ, Ho J. MicroRNA-17~92 Is Required for Nephrogenesis and Renal Function. J Am Soc Nephrol. 2017, Jul;25(7):1440-52. PMCID PMC4073423
Montalbetti, N, Rued AC, Taiclet SN, Birder LA, Kullmann FA, Carattino MD. Urothelial tight junction barrier dysfunction sensitizes bladder afferents. eNeuro. 2017, May 24;4(3): ENEURO.0381-16. PMCID PMC5442440
Mukherjee A, Wang Z, Kinlough CL, Poland PA, Marciszyn AL, Montalbetti N, Carattino MD, Butterworth MB, Kleyman TR, Hughey RP. Specific Palmitoyltransferases Associate with and Activate the Epithelial Sodium Channel. J Biol Chem. 2017, Mar 10;292(10):4152-4163. PMCID PMC5354509.
Mukherjee E, Maringer K, Papke E, Bushnell D, Schaefer C, Kramann R, Ho J, Humphreys BD, Bates C, Sims-Lucas S. Endothelial marker-expressing stromal cells are critical for kidney formation. Am J Physiol Renal Physiol. 2017 Sep 1;313(3):F611-F620. PMCID: In process.
Muller L, Simms P, Hong CS, Nishimura M, Jackson EK, Watkings S, and Whiteside TL. Human tumor-derived exosomes (TEX) are not internalized by T lymphocytes but signal via surface receptors to induce cellular responses. OncoImmunology 2017, In press. PMCID In process
Nakasone MA, Lewis TA, Walker O, Thakur A, Mansour W, Castañeda CA, Goeckeler-Fried JL, Parlati F, Chou TF, Hayat O, Zhang D, Camara CM, Bonn SM, Nowicka UK, Krueger S, Glickman MH, Brodsky JL, Deshaies RJ, Fushman D. Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway. Structure. 2017 Dec 5;25(12):1839-1855.e11. PMCID: PMC5731780.
Narla D, Slagle S, Schaefer C, Bushnell D, Bates CM. Loss of peri-Wolffian duct stromal Frs2α expression in mice leads to abnormal ureteric bud induction and vesicoureteral reflux, Pediatric Research. 2017, In press, PMCID In process.
Nickerson KM, Wang Y, Bastacky S, Shlomchik MJ. Toll-like receptor 9 suppresses lupus disease in Fas-sufficient MRL Mice. PLoS One. 2017 Mar 9;12(3):e0173471. PMCID PMC5344451.
O'Donnell BM, Mackie TD, Subramanya AR, Brodsky JL. Endoplasmic reticulum-associated degradation of the renal potassium channel, ROMK, leads to type II Bartter syndrome. J Biol Chem. 2017, Aug 4;292(31):12813-12827. PMCID PMC5546024
Pavlov TS, Levchenko V, Ilatovskaya DV, Li H, Palygin O, Pastor-Soler NM, Hallows KR, Staruschenko A. Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats. Front Physiol. 2017, Apr 20;8:227. PMCID PMC53975
Pradhan D, Amin M, Hooda S, Dhir R, Bastacky S, Parwani AV. Utility of the laminin immunohistochemical stain in distinguishing invasive from noninvasive urothelial carcinoma. J Cancer Res Ther. 2017 Oct-Dec;13(6):947-950. PMCID: In Process.
Preston GM, Brodsky JL. The evolving role of ubiquitin modification in endoplasmic reticulum-associated degradation. Biochem J. 2017, Feb 15;474(4):445-469. PMCID PMC5425155
Puri P, Schaefer CM, Bushnell D, Taglienti ME, Kreidberg JA, Yoder BK, Bates CM. Ectopic Phosphorylated Creb Marks Dedifferentiated Proximal Tubules in Cystic Kidney Disease. Am J Pathol. 2018 Jan;188(1):84-94. PubMed PMID: 29107072; PMCID: PMC5745541
Ray, E.C. and T.R. Kleyman. An increasingly complex relationship between salt and water. Am J Kidney Dis. 2017, In Press. PMCID In process
Salah EM, Bastacky SI, Jackson EK and Tofovic SP. Captopril attenuates cardiovascular and renal disease in a rat model of heart failure with preserved ejection fraction. J Cardiovasc Pharmacol. In press. PMCID: In process.
Shi S, Carattino MD. Expression and Analysis of Flow-regulated Ion Channels in Xenopus Oocytes. Bio Protoc. 2017, Apr 20;7(8): e2224. PMCID PMC5493207.
Shi, S., T.M. Buck, C.L. Kinlough, A.L. Marciszyn, R.P. Hughey, M. Chalfie, J.L. Brodsky and T.R. Kleyman. Regulation of the epithelial Na+ channel by paraoxonase-2. J. Biol. Chem. 2017, In press. PMCID In process
Shimizu N, Doyal MF, Goins WF, Kadekawa K, Wada N, Kanai AJ, de Groat WC, Hirayama A, Uemura H, Glorioso JC, Yoshimura N. Morphological changes in different populations of bladder afferent neurons detected by herpes simplex virus (HSV) vectors with cell-type-specific promoters in mice with spinal cord injury. Neuroscience. 2017 Nov 19;364:190-201. PMCID: PMC5768486.
Shun T, Gough AH, Sanker S, Hukriede NA, Vogt A. Exploiting Analysis of Heterogeneity to Increase the Information Content Extracted from Fluorescence Micrographs of Transgenic Zebrafish Embryos. Assay Drug Dev Technol. 2017 Aug/Sep;15(6):257-266. PMCID: PMC5576098
Unruh ML, Pankratz VS, Demko JE, Ray EC, Hughey RP, Kleyman TR. Trial of Amiloride in Type 2 Diabetes with Proteinuria. Kidney Int. Rep. 2017, In press. PMCID: In Process
Ye Z, Needham PG, Estabrooks SK, Whitaker SK, Garcia BL, Misra S, Brodsky JL, Camacho CJ. Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase. Sci Rep. 2017, May 11;7(1):1789. PMCID PMC5431976
Zacchi LF, Dittmar JC, Mihalevic MJ, Shewan AM, Schulz BL, Brodsky JL, Bernstein KA. A novel high-throughput yeast genetic screen for factors modifying protein levels of the Early-Onset Torsion Dystonia-associated variant torsinAΔE. Dis Model Mech. 2017, In press. PMCID in process
Zhou D, Fu H, Zhang L, Zhang K, Min Y, Xiao L, Lin L, Bastacky SI, Liu Y. Tubule-Derived Wnts Are Required for Fibroblast Activation and Kidney Fibrosis. J Am Soc Nephrol. 2017, Aug;28(8):2322-2336. PMCID PMC5533232
Zhou D, Tian Y, Sun L, Zhou L, Xiao L, Tan RJ, Tian J, Fu H, Hou FF, Liu Y. Matrix Metalloproteinase-7 Is a Urinary Biomarker and Pathogenic Mediator of Kidney Fibrosis. J Am Soc Nephrol. 2017, Feb;28(2):598-611. PMCID PMC5280025.
Zhu X, Jackson EK. RACK1 regulates angiotensin II-induced contractions of SHR preglomerular vascular smooth muscle cells. Am J Physiol Renal Physiol 2017, Apr 1;312(4):F565-F576. PMCID PMC5407068